ADAPTATION TO THE STRESS OF ACADEMIC EXAMINATIONS IN MEDICAL STUDENTS: INCREASED ANTIOXIDANT DEFENSE AND NEUROTROPHIC FACTOR DERIVED FROM THE BRAIN

Carla Patricia CARLOS, Patricia Maluf CURY, Fernanda do Nascimento Pessatto QUESSADA, Thaysa Castro MOLINA, Flavio Pereira dos SANTOS JÚNIOR, Hugo Aidar Vicente dos SANTOS, Luis Fernando de BUENO

Resumen


Academic examination may cause stress and promote oxidative stress, producing metabolites that can lead to cell damage and death. On the other hand, it involves learning and memorization, requiring the production of neurotrophic factors. Thus, we aimed to analyze oxidative stress and neurotrophic factor markers in the plasma of medical students under academic assessments. For this, two blood samples were collected from 30 students in the 7th semester of their medicine degree, in the period immediately following the vacations, and minutes before academic assessments. The stress of students was investigated by applying Lipp Inventory of Stress Symptoms for Adults (ISSL) during blood samples collections. Oxidative stress was verified by 

measuring TBARS (thiobarbituric acid reactive substances) and TEAC (trolox equivalent antioxidant capacity); neurotrophic factor was measured by evaluating BDNF (brain-derived neurotrophic factor) concentration. No significant difference was found in the stress of the students in the two contexts studied, with the resistance phase predominating among the stressed students. The TBARS concentration did not differ between samples. However, TEAC was higher on the day of the assessments, with a positive correlation between these two parameters, accompanied by an increase in BDNF. We conclude that occurs elevation of antioxidant defense in order to maintain the redox equilibrium in plasma of medical students at pre-examinations. This is followed by increased BDNF that may favor the learning and academic performance.

 Keywords: BDNF; Stress; psychological stress; oxidative stress; academic performance.


Palabras clave


BDNF; Stress; psychological stress; oxidative stress; academic performance.

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Referencias


AGUIAR, S. M., Vieira, A. P. G. F., Vieira, K. M. F., Aguiar, S. M., & Nóbrega, J. O. (2009). Prevalência de sintomas de estresse nos estudantes de medicina. Jornal Brasileiro de Psiquiatria, 58(1), 34-38.

BARBOSA, K. B. F., Costa, N. M. B., Alfenas, R. d. C. G., De Paula, S. O., Minim, V. P. R., & Bressan, J. (2010). Estresse oxidativo: conceito, implicações e fatores modulatórios. Revista de nutrição, 23(4), 629-643.

BATHINA, S., & Das, U. N. (2015). Brain-derived neurotrophic factor and its clinical implications. Archives of medical science: AMS, 11(6), 1164.

BRITO, M. V., Yasojima, E. Y., Percario, S., Ribeiro, R. F. J., Cavalcante, L. C., Monteiro, A. M., . . . Santos, H. A. (2017). Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats. Acta Cir Bras, 32(3), 211-218. doi:10.1590/s0102-865020170030000005

ESKIOCAK, S., Gozen, A., Yapar, S., Tavas, F., Kilic, A., & Eskiocak, M. (2005).

Glutathione and free sulphydryl content of seminal plasma in healthy medical students during and after exam stress. Human reproduction, 20(9), 2595-2600.

GRAY, J., Milner, T., & McEwen, B. (2013). Dynamic plasticity: the role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors. Neuroscience, 239, 214-227.

HUNDERTMARK, J., Alvarez, S., Loukanova, S., & Schultz, J.-H. (2019). Stress and stressors of medical student near-peer tutors during courses: a psychophysiological mixed methods study. BMC medical education, 19(1), 95.

KAM, S. X. L., Toledo, A. L. S. d., Pacheco, C. C., Souza, G. F. B. d., Santana, V. L. M., Bonfá-Araujo, B., & Custódio, C. R. d. S. N. (2019). Estresse em Estudantes ao longo da Graduação Médica. Revista Brasileira de Educação Médica, 43(1), 246-253.

KOMULAINEN, P., Pedersen, M., Hänninen, T., Bruunsgaard, H., Lakka, T. A., Kivipelto, M., . . . Rauramaa, R. (2008). BDNF is a novel marker of cognitive function in ageing women: the DR’s EXTRA Study. Neurobiology of learning and memory, 90(4), 596-603.

LEAL, G., Bramham, C. R., & Duarte, C. B. (2017). BDNF and Hippocampal Synaptic Plasticity. Vitam Horm, 104, 153-195. doi:10.1016/bs.vh.2016.10.004

LIMA, R. L. d., Soares, M. E. C., Prado, S. N. d., & Albuquerque, G. S. C. d. (2016). Estresse do Estudante de medicina e rendimento acadêmico. Revista Brasileira de Educação Médica, 40(4), 678-684.

LIPP, M. E. N. (2000). Manual do inventário de sintomas de stress para adultos de Lipp (ISSL). São Paulo: Casa do Psicólogo, 76.

LORICCHIO, T. M. B., & Leite, J. R. (2012). Estresse, ansiedade, crenças de autoeficácia e o desempenho dos bacharéis em Direito. Avaliação Psicológica, 11(1), 37-47.

LUSHCHAK, V. I. (2014). Free radicals, reactive oxygen species, oxidative stress and its classification. Chem Biol Interact, 224, 164-175. doi:10.1016/j.cbi.2014.10.016

MONDARDO, A. H., & Pedon, E. A. (2005). Estresse e desempenho acadêmico em estudantes universitários. Revista de Ciências Humanas, 6(6), 159-180.

PANI, S., Al Khabbaz, H., Bin Enayeg, S., & Bin Zouman, A. (2017). The relationship between examination‐related academic stress, salivary antioxidant capacity and exercise patterns of final‐year Saudi dental students. European Journal of Dental Education, 21(4), e83-e88.

PEREIRA, F. (2011). Etiopatologia geral das lesões. In G. Filho (Ed.), Bogliolo Patologia (8 ed., pp. 23-76). Rio de Janeiro: Guanabara-Koogan.

SALIM, S. (2017). Oxidative Stress and the Central Nervous System. J Pharmacol Exp Ther, 360(1), 201-205. doi:10.1124/jpet.116.237503

SANTOS, V. S. D. S., Zortea, M., Alves, R. L., Naziazeno, C. C. D. S., Saldanha, J. S., Carvalho, S. D. C. R., . . . Caumo, W. (2018). Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial. Sci Rep, 8(1), 12477. doi:10.1038/s41598-018-30127-z

SELYE, H. (1950). Stress and the general adaptation syndrome. Br Med J, 1(4667), 1383-1392. doi:10.1136/bmj.1.4667.1383

SILVA, C. T. d., & Jasiulionis, M. G. (2014). Relação entre estresse oxidativo, alterações epigenéticas e câncer. Ciência e Cultura, 66(1), 38-42.

SIVOŇOVÁ, M., Žitňanová, I., Hlinčíková, L., Škodáček, I., Trebatická, J., & Ďuračková, Z. (2004). Oxidative stress in university students during examinations. Stress, 7(3), 183-188.

TEIXEIRA, R. R., Díaz, M. M., Santos, T. V., Bernardes, J. T., Peixoto, L. G., Bocanegra, O. L., . . . Espindola, F. S. (2015). Chronic stress induces a hyporeactivity of the autonomic nervous system in response to acute mental stressor and impairs cognitive performance in business executives. PLoS One, 10(3), e0119025. doi:10.1371/journal.pone.0119025

VOGEL, S., & Schwabe, L. (2016). Learning and memory under stress: implications for the classroom. npj Science of Learning, 1(1), 1-10.




DOI: http://dx.doi.org/10.21902/RevPercurso.2316-7521.v6i37.6070

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